马戏团主任艾蒙多（里卡多·蒙特尔班 Ricardo Montalban 饰）收留并保护了一只孤苦无依的猩猩，取名凯撒（罗迪·麦克道尔 Roddy McDowall 饰）。在艾蒙多无微不至的关怀下，凯撒渐渐长大，它和“父亲”艾蒙多之间的关系十分亲密。 一场病毒的肆虐让猫和狗在地球上绝迹了，失去了最忠诚的朋友们，需要动物们陪伴的人类将目光转向了和他们极为相像的猩猩，就这样，饲养猩猩当做宠物成为了新的时尚。然而，人类的残暴本性使得这些原本温顺善良的猩猩们生活苦不堪言，它们被折磨虐待，永远的失去了自由。终于，猩猩们决定不再忍耐，在凯撒的带领下，它们英勇起义，发誓定要推翻人类的压迫和统治。
After seventeen years in prison, the former respected Parisian banker Paul Lavond flees with his friend, the lunatic scientist Marcel that is researching with his wife Malita the miniaturization of animals and human beings to improve the resources of mankind. Paul Lavond was framed for robbery by his scoundrel associates Emil Coulvet, Charles Matin and Victor Radin that had stolen his business while his family was doomed to shame, poverty and tragedy. When Marcel reduces the retarded servant Lachna, he learns that the woman is motionless and only responds to the control of his brain and has a heart attack. After the death of Marcel, Paul Lavond sees the chance to use the miniaturization process as instrument of vengeance and he travels to Paris with the insane Malita disguised of Madame Mandilip, a nice old lady and owner of a dolls store. Paul Lavond, using the identity of Madame Mandilip, befriends his resented and estranged daughter Lorraine Lavond and plots a scheme to revenge and vindicate his family name.
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